Ingredients & Active Compounds

Royal Jelly: Scientific Insights and Health Benefits from 30+ Years of Expertise

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Royal Jelly Scientific Insights and Health Benefits from 30+ Years of Expertise

Royal Jelly Benefits are increasingly supported by scientific research, particularly regarding immunity, skin health, cognition, and metabolic balance. In this article, we review the composition of royal jelly, the role of 10-HDA, and key clinical evidence to help practitioners and brands make informed formulation choices.

Q&A

What is royal jelly used for?

Royal jelly is traditionally used to support the immune system, reduce fatigue, and promote vitality. Modern studies also highlight benefits for skin health (collagen synthesis, anti-aging effects), cognitive function (memory and concentration), and hormonal balance, especially during menopause. Its richness in proteins, vitamins, minerals, and the unique fatty acid 10-HDA makes it a versatile supplement for overall well-being.

What is the difference between fresh and lyophilized royal jelly?

  • Fresh royal jelly must be stored in cold conditions (refrigerated or frozen) to maintain stability. It is often sold in jars or bulk bags, making it suitable for liquid forms such as ampoules or direct consumption.

  • Lyophilized royal jelly is freeze-dried, which preserves its nutrients while allowing room-temperature storage. It is particularly useful for capsules, tablets, or powder mixes, and can deliver up to 3 times higher concentrations of 10-HDA per gram.

Can royal jelly be consumed all year long?

Yes, but most experts recommend taking it in 4–6 week cycles, ideally on an empty stomach in the morning, to maximize absorption. This approach prevents the body from adapting too quickly and helps maintain the effectiveness of the supplement. Some people use RJ seasonally (winter, stress periods, convalescence), while others incorporate it regularly for long-term vitality and immune resilience.

What are possible side effects?

Side effects are rare, but individuals allergic to bee products should exercise caution. Reported reactions may include mild digestive discomfort, skin rash, or respiratory symptoms in sensitive individuals. It is advisable to start with small amounts, especially if you have a history of allergies. Pregnant or breastfeeding women should consult a healthcare professional before supplementation.

What formats does CEVRAI offer?

Laboratoire CEVRAI supplies royal jelly in multiple forms to meet both professional and consumer needs:

  • Bulk fresh royal jelly (1, 5, or 10 kg) shipped in isothermal boxes.

  • Jars (10 g, 25 g, 30 g, 100 g) – available in organic or conventional quality.

  • Syringes of 10 g for precise dosing.

  • Ampoules or CelsDose® shots (glass or plastic, customizable dosages).

  • Lyophilized powder standardized in 10-HDA, primarily for capsule or tablet manufacturing.

Why choose CEVRAI?

For more than 30 years, CEVRAI has been a trusted partner in royal jelly production and nutraceutical innovation. The laboratory guarantees:

  • Premium sourcing from certified beekeepers.

  • Strict quality standards with ISO, GMP, and Ecocert certifications.

  • Customized solutions, from bulk supply to finished product packaging.

  • International expertise, supporting brands in Europe and Asia.

  • Sustainability commitment, ensuring traceability and environmental responsibility.

royal jelly anti aging cevrai

Applications in Nutraceuticals and Health Products

Royal jelly is an ingredient of choice in:

  • Dietary supplements: capsules, ampoules, sticks, powders.

  • Functional foods & beverages: natural energy boosters.

  • Nutricosmetics: anti-aging and skin regeneration formulations.

  • Seasonal cures: immunity and vitality support during winter or recovery periods.

Scientifically Documented Benefits of Royal Jelly

🛡️ Immunity — 10-HDA and Immune Modulation

Royal jelly contains unique fatty acids such as 10-HDA/10HDAA and bioactive peptides that act as natural modulators of the immune system. These compounds stimulate innate immune pathways, including macrophage activity and cytokine balance. Recent work shows that fermentation can increase the content of active fatty acids, thereby boosting the immune-enhancing potential of RJ — an exciting perspective for natural defense formulations.

📖 Reference: Itatani H. et al., 2025, Fermented Royal Jelly Enriched With 10-Hydroxydecanoic Acid (10HDAA)… (experimental study showing enhanced immunostimulatory activity by increasing 10HDAA content).

⚡ Energy & Metabolism — Vitality and Endurance

Beyond its rich profile of B-vitamins and amino acids, royal jelly is now being studied in human clinical trials for its effects on fatigue, muscle recovery, and performance. A recent RCT among athletes reported that daily RJ supplementation improved endurance markers and reduced post-exercise muscle damage. This positions RJ as a credible ingredient for sports nutrition and vitality supplements.

📖 Reference (Clinical Trial): Pasdar Y. et al., 2025, Royal jelly supplementation improves endurance and… (randomized trial in trained subjects).

✨ Skin & Anti-Aging — Collagen and Photoaging

Royal jelly supports skin health through fibroblast stimulation and collagen synthesis, combined with strong antioxidant and anti-inflammatory activity. These mechanisms protect against oxidative stress and UVB-induced photoaging. Recent reviews confirm RJ’s role in nutricosmetics, reinforcing its value as a natural anti-aging ingredient for firmness, elasticity, and radiance.

📖References:

🧠 Cognition — Neuroprotection and Mental Performance

Royal jelly contains neuroprotective compounds with antioxidant, cholinergic-like, and anti-inflammatory properties. These effects may protect neurons from oxidative stress and support memory and attention. Recent reviews highlight RJ’s potential to improve cognitive resilience and encourage further clinical studies. This makes RJ a promising ingredient for focus and brain-health formulations.

📖 Reference (Review): Zhu F. et al., 2024/2025, Neuroregulatory effect of royal jelly (review of mechanisms and therapeutic perspectives).

👩‍🦳 Hormonal Balance — Menopause & Quality of Life

One of the most compelling human studies on RJ showed that daily supplementation reduced menopausal symptoms after only eight weeks. More recent reviews confirm that RJ exerts estrogen-like activity through 10-HDA and may influence FSH/LH regulation. This supports its use in targeted formulations for women’s health, aiming to improve hormonal balance and overall quality of life during menopause.

📖 References:

Royal Jelly Benefits extend beyond general vitality. Evidence links 10-HDA to innate immune modulation and reduced low-grade inflammation (see the 10-HDA immunomodulation study on PubMed). In skin health, fibroblast stimulation supports collagen synthesis and firmness, a core anti-aging mechanism reported in Journal of Medicinal Food. For cognition, recent reviews (Heliyon) summarize neuroprotective pathways relevant to memory and attention.

How to Integrate Royal Jelly in Your Formulations (How-To Guide)

1️⃣ Select the right form:

fresh (higher bioactivity) or lyophilized (better stability).

2️⃣ Adapt the dosage:

from 200mg/day in capsules to 1,000–2,000mg/day in ampoules.

3️⃣ Choose the delivery system:

Bulk fresh royal jelly for industrial use.Vacuum-packed jars for retail sales.Capsules for dietary supplements (standardized in 10-HDA).Ampoules or CelsDose® for functional beverages.

4️⃣ Combine with synergistic ingredients:

ginseng, pollen, or propolis to amplify effects.

Conclusion : 

Why Choose CEVRAI?

In summary, Royal Jelly Benefits are underpinned by growing clinical and mechanistic evidence, with 10-HDA as a key marker of quality. For practitioners and brands, choosing standardized inputs and suitable delivery forms (capsules, ampoules, CelsDose®) is essential to translate research into outcomes.

Royal jelly is much more than a simple bee product: it is a nutrient-dense ingredient whose benefits are supported by both tradition and modern science. From immunity and energy to skin health, cognition, and hormonal balance, its applications are remarkably broad.

Backed by over 30 years of expertise, Laboratoire CEVRAI provides both organic and conventional royal jelly, available in fresh, lyophilized, or retail formats, ensuring quality, traceability, and scientific credibility. Whether you are a professional developing innovative supplements or a consumer looking for natural vitality, royal jelly remains a powerful and versatile option.

For more than 30 years, Laboratoire CEVRAI has supplied premium-quality royal jelly, both organic and conventional. Our expertise ensures purity, traceability, and compliance with international standards (ISO, GMP, Ecocert).

We offer:

Fresh royal jelly (decongelated) in 1kg, 5kg, and 10kg bags (bulk orders available online), shipped in isothermal boxes.

Retail packaging: jars of 10g, 25g, 30g, or 100g, and 10g syringes.

Organic 30g jars – Royaume de la Nature®.

Conventional 10g jars – unbranded.

Lyophilized royal jelly for capsule manufacturing, with high 10-HDA content for superior efficacy.

Looking for bulk ?

Purchase online our EU compliant Bulk Royal Jelly or our branded ready to sell  Royal Jelly 30g – Organic Brand Royaume de la Nature® 

📦 Curious about our production constraints and industrial requirements?

Go to our personalized tool to develop your supplement

References

  • Kohno, K., Okamoto, I., Sano, O., Arai, N., Iwaki, K., Ikeda, M., & Kurimoto, M. (2004). Anti-inflammatory and immune-modulating activities of 10-hydroxy-2-decenoic acid, a unique fatty acid from royal jelly. Journal of Biological Chemistry, 279(14), 13874–13880. https://doi.org/10.1074/jbc.M311286200

  • Morita, H., Ikeda, T., Kajita, K., Fujioka, K., Mori, I., Okada, H., Uno, Y., Ishizuka, T., Ishizawa, S., Saito, Y., Sakamoto, S., & Takahashi, T. (2012). Effect of royal jelly ingestion for six months on healthy volunteers. Nutrition Journal, 11(1), 77. https://doi.org/10.1186/1475-2891-11-77

  • Park, H. M., Hwang, E., Lee, K. G., Han, S. M., Cho, Y., & Kim, S. Y. (2011). Royal jelly protects skin against ultraviolet B-induced photoaging in human skin fibroblasts. Journal of Medicinal Food, 14(9), 904–910. https://doi.org/10.1089/jmf.2010.0177

  • Zhu, F., Xu, J., Chen, J., Ye, H., Yu, J., & others. (2024). Neuroregulatory effect of royal jelly: Mechanisms and therapeutic perspectives. Heliyon, 10(3), e28203. https://doi.org/10.1016/j.heliyon.2024.e28203

  • Sharif, S. N., Darsareh, F., Alizadeh, Z., Javadivala, Z., & Bahrami, A. (2019). Effect of royal jelly on menopausal symptoms in postmenopausal women: A randomized clinical trial. Evidence-Based Complementary and Alternative Medicine, 2019, 1–7. https://doi.org/10.1155/2019/4865915

  • Oršolić, N., Landeka Jurčević, I., & others. (2024). Royal jelly: Biological action and health benefits. International Journal of Molecular Sciences, 25(11), 6023. https://doi.org/10.3390/ijms25116023

  • Oršolić et al. 2024, “Royal Jelly: Biological Action and Health Benefits” — for mechanistic evidence, mention of menopause symptoms, estrogenic effects. PubMed+1

  • Sharif et al. 2019, “Effect of royal jelly on menopausal symptoms” — clinical evidence of symptom relief. PubMed

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